Publications
A record
of scholarly
work.
95
Works on
ORCID
ORCID
27
Journal
articles
articles
17
Datasets and
preprints
preprints
10
DrugSynthAI
program papers
program papers
1
Book
(ISBN)
(ISBN)
I.
Peer reviewed
Peer reviewed articles.
Articles passing formal peer review. DOI links resolve to the publisher version of record.
2026
JAMIA Open · Oxford
Auditing shortcut learning and misclassification in artificial intelligence based breast cancer genomic subtyping
Harvard GCSRT capstone. Originally developed as Hidden Biases in AI Powered Breast Cancer Genomic Subtype Prediction. Dataset on Dryad 10.5061/dryad.fj6q57482
JAMIA Open Volume 9, Issue 2, April 2026
2026
AI in Health · AccScience
Machine learning insights for cardiovascular risk prediction in diabetic patients: emphasis on renal and cardiac markers using random forests
Leakage resistant evaluation with stratified five fold CV. SSRN preprint 5091734
Artificial Intelligence in Health 2026
2026
AJBSR
Clinical Artificial Intelligence as a Sociotechnical System: Structural Failure Modes and Governance Requirements
Am J Biomed Sci & Res 30(1) MS.ID.003888
2025
Endocrinology
Thromboembolic Risk and Testosterone Replacement Therapy: Debunking Myths and Clarifying Evidence
Int. J. Diabetes Management Vol 4, Issue 1
2024
Cardiology
Precision Medicine in Cardiology: An Evolving Understanding of Biomarkers in Coronary Artery Disease Prevention, a 10-Year Thematic Review
Cardiology and Cardiovascular Medicine 8(4)
2024
Endocrinology
The Inverse Association between Testosterone Replacement Therapy and Cardiovascular Disease Risk: A 25 Year Systematic Review and Meta-Analysis
Int. J. Cardiovascular Medicine
2024
Cardiology
Translational Cardiology: Practical Insights into the Coenzyme Q10 Role as Potential Therapeutic Agent for Cardiovascular Disease, A Systematic Review and Meta-Analysis
Translational Medicine Open Access
2024
Cardiology
Dietary Sodium and Cardiovascular Risk: A Systematic Review and Meta-Analysis
Am J Biomed Sci & Res
2024
Cardiology
Potassium Intake and Cardiovascular Risk: A Systematic Review and Meta-Analysis of Prospective Cohort Studies
Biomed J Sci & Tech Res
2024
Urology
Erectile Dysfunction as a Novel Biomarker for the Onset of Cardiometabolic Vascular Disease Risk in the Aging Male: A Systematic Review and Meta-Analysis
Advances in Urology and Nephrology
2024
Pain Medicine
Mitigating the Opioid Epidemic: The Role of Cannabinoids in Chronic Pain Management, A Systematic Review and Meta-Analysis of Clinical Evidence and Mechanisms
J. Anesthesia & Pain Medicine
2024
AI · Pain
Artificial Intelligence in Pain Management: Advancing Translational Science in Digital Health Research from Bench to Bedside
Advances in Machine Learning & AI
2024
Preventive Medicine
Trends in Sudden Cardiac Death in Pilots: A Post COVID-19 Challenging Crisis of Global Perspectives (2011-2023), A Systematic Review and Meta-Analysis
Int. J. Preventive Medicine and Care 2(2)
2024
Cardiology
Innovative E-Health Technologies for Cardiovascular Disease Treatment: A 2024 Updated Systematic Review and Meta-Analysis
Medical Devices & Surgical Technology Week
2024
Psychiatry
Neuroplasticity Alterations Induced by Isotretinoin Use in RARA Gene Polymorphism is Associated with Increased Risk of Depression and Suicidal Ideation in Patients with Vitamin D Deficiency
J. Psychiatry Research Reviews & Reports
2024
Endocrinology
Oral Testosterone Therapy in Hypogonadal Men: A Comprehensive Systematic Review and Meta-Analysis of Safety, Efficacy, and Secondary Health Outcomes
J. Series Endocrinology, Diabetes and Metabolism
2024
Endocrinology
The Promise and Challenges of Oral Testosterone Therapy
MedNEXT J. Medical and Health Sciences
2024
Nutrology
Major Clinical Outcomes and Discussions of the Impacts of Religiosity and Spirituality in Patients with Palliative Care and Nutrology Therapy: A Concise Systematic Review
Int. J. Nutrology (Indexed)
II.
Research program 01
Clinical AI Governance.
The foundational series of the Governing Adaptive Clinical Artificial Intelligence research program. Eight papers establishing formal theory, empirical audit, and deployable infrastructure, plus a program statement. Two peer reviewed in 2026 (JAMIA Open and Am J Biomed Sci & Res, listed in Section I above), the remainder under peer review or in the SSRN record.
2026
Paper #1 · Theory
Externally Governed Learning Systems: Adaptive Computation Under Viability Constraints
Foundation of US Provisional Patent 63/975,551 · Harvard GCSRT shortcut learning thesis
SSRN Preprint
2026
Paper #4 · Policy
Payer Mediated Artificial Intelligence Governance and Reimbursement Driven Algorithm Behavior in United States Healthcare
SSRN January 31, 2026
2026
Paper #5 · Methods
Multi Armed Bandit Based Adaptive Model Selection for Clinical AI Governance: An Infrastructure Approach to Safer AI Use in U.S. Healthcare
Dataset on Zenodo 10.5281/zenodo.18248286
Research Square Preprint
2026
Paper #6 · Infrastructure
Adaptive FHIR Native AI Governance for Clinical Decision Support
Dataset on Zenodo 10.5281/zenodo.18356747
Research Square Preprint
2026
Paper #7 · Equity
Auditable AI for Genomic Equity: A Compliance as a Service Model for Responsible Innovation
SSRN January 26, 2026
2026
ML · CVD
Machine Learning Insights for Cardiovascular Risk Prediction in Diabetic Patients: Emphasis on Renal and Cardiac Markers Using Random Forests
Research Square Preprint
2026
Paper #8 · Standard
Externally Governed Learning Systems (EGLS): A Structural Governance Standard for Adaptive and Learning Systems
Governance specification paper accompanying US Provisional Patent 63/975,551
SSRN Electronic Journal 2026
2026
Program
Governing Adaptive Clinical Artificial Intelligence: Structural Failure Modes, Auditability, and Infrastructure for Decision Safety (v1.0)
Mirror on SSRN 6173978
Zenodo Program paper
III.
Research program 02
DrugSynthAI and MitoCoreX.
A ten paper research program on governed AI for drug discovery, plus a four paper thesis track (GeneVector) on therapeutic candidate evaluation standards. Submitted in parallel across SSRN, Zenodo, ChemRxiv, and Research Square. Target journals include JAMIA, Briefings in Bioinformatics, Journal of Translational Medicine, Drug Discovery Today, and others.
2026
GeneVector Track
The Therapeutic Candidate Decision Record (TCDR): A Computable Representation and Minimum Information Standard for Translational Therapeutics
GeneVector Paper 1 of 4. Open code: github.com/fxmedus/genevector-track
SSRN May 2026
2026
GeneVector Track
Structured Multi Criteria Evaluation of Computationally Generated Therapeutic Candidates: A Case Series from the MitoCoreX Mitochondrial Drug Discovery Pipeline
GeneVector Paper 3 of 4. Twenty candidates across five mitochondrial targets.
SSRN May 2026
2026
GeneVector Track
The Evidence Readiness Index: A Budget Constrained Optimization Framework for Translational Gap Resolution in Computational Drug Discovery
GeneVector Paper 4 of 4. Knapsack optimization across eight evidence gaps.
SSRN May 2026
2026
Architecture
Mitochondrial Pathway Architecture: A Systems Level Map of Target Connectivity for Precision Drug Design (v1.0)
Zenodo Dataset
2026
Druggability
Computational Druggability Assessment of Mitochondrial Targets: Structure Function Constraints and Binding Site Characterization
ChemRxiv Preprint
2026
Variant modelling
Molecular Consequence Modeling of Mitochondrial Gene Variants: A Functional Defect Classification System for Precision Drug Design (v1.0)
Zenodo Dataset
2026
Pipeline
DrugSynth AI: An Artificial Intelligence Pipeline for De Novo Molecule Design Targeting Genetically Defined Mitochondrial Defects (v1.0)
Zenodo Dataset
2026
Proof of concept
AI Assisted De Novo Design of Small Molecule Candidates Targeting Five Priority Mitochondrial Proteins: A MitoCoreX Proof of Concept (v1.0)
Also on ChemRxiv 10.26434/chemrxiv.15001592/v1
Zenodo Dataset
2026
Pharmacology
In Silico Pharmacological Profiling of MitoCoreX Candidate Molecules: ADMET, Target Engagement, Selectivity, and Stability Analysis (v1.0)
Zenodo Dataset
2026
End to end
MitoCoreX: A Validated AI Pipeline for Precision Drug Design Targeting Genetically Defined Mitochondrial Disease — End to End Proof of Concept (v1.0)
Zenodo Dataset
2026
ADMET
ADMET Profiling of a Mitochondria Focused Compound Library: Physicochemical Baselines, Membrane Permeability Classification, and Tier Based Filtering for AI Driven Drug Discovery
ChemRxiv April 1, 2026
2026
Scaffolds
Pan Mitochondrial Privileged Scaffolds: Adenine, Pyridine, and a 7H Purine Bioisostere as Multi Target Fragments in the MitoCoreX Drug Discovery Campaign
Zenodo Dataset
2026
Mendelian randomization
Genetically Instrumented CYP19A1 Whole Blood Expression and Autism Spectrum Disorder Risk: A Two Sample Mendelian Randomization Study
Submitted to BMC Medical Genomics
Zenodo Dataset
2026
Meta-analysis
HFE Genotype and Neurodegeneration: An Updated Systematic Review and Structured Evidence Synthesis with Four Stratum Architecture
Accepted, Alzheimer's Research & Therapy
Research Square Preprint
IV.
Research program 03
Endocrinology and cardiology.
Clinical and translational work in endocrinology, cardiology, preventive medicine, and digital health, drawing on twenty plus years of clinical practice.
| Year | Title | Venue | DOI |
|---|---|---|---|
| 2025 | Thromboembolic Risk and Testosterone Replacement Therapy | Int. J. Diabetes Management | 10.61797/ijdm.v4i1.433 |
| 2024 | Trends in Sudden Cardiac Death in Pilots: A Post COVID-19 Challenging Crisis of Global Perspectives (2011-2023), A Systematic Review and Meta-Analysis | Int. J. Preventive Medicine and Care 2(2) | 10.33140/IJPMC.02.02.04 |
| 2024 | Precision Medicine in Cardiology: An Evolving Understanding of Biomarkers in Coronary Artery Disease Prevention, a 10-year Thematic Review | Cardiology and Cardiovascular Medicine 8(4) | 10.26502/fccm.92920395 |
| 2024 | The Inverse Association between Testosterone Replacement Therapy and Cardiovascular Disease Risk: A 25 Year Systematic Review | Int. J. Cardiovascular Medicine | 10.31579/2834-796X/073 |
| 2024 | Translational Cardiology: Role of Coenzyme Q10 in Cardiovascular Disease | Translational Medicine Open Access | 10.33140/tmoa.02.01.04 |
| 2024 | Dietary Sodium and Cardiovascular Risk | Am J Biomed Sci & Res | 10.34297/AJBSR.2024.23.003132 |
| 2024 | Potassium Intake and Cardiovascular Risk | Biomed J Sci & Tech Res | 10.26717/BJSTR.2024.59.009289 |
| 2024 | Erectile Dysfunction as a Novel Biomarker for Cardiometabolic Risk | Advanced J. Urology & Nephrology | 10.33140/AJUN.06.01.06 |
| 2024 | Mitigating the Opioid Epidemic: The Role of Cannabinoids in Chronic Pain Management, A Systematic Review and Meta-Analysis of Clinical Evidence and Mechanisms | J. Anesthesia & Pain Medicine | 10.33140/JAPM.09.03.05 |
| 2024 | Artificial Intelligence in Pain Management: Advancing Translational Science in Digital Health Research from Bench to Bedside | Advances in ML & AI | 10.33140/amlai.05.03.04 |
| 2024 | Innovative E-Health Technologies for Cardiovascular Disease Treatment: A 2024 Updated Systematic Review and Meta-Analysis | Medical Devices & Surgical Technology Week · medRxiv | 10.1101/2024.06.29.24309706 |
| 2024 | Neuroplasticity Alterations Induced by Isotretinoin Use in RARA Gene Polymorphism is Associated with Increased Risk of Depression and Suicidal Ideation in Patients with Vitamin D Deficiency | J. Psychiatry Research Reviews & Reports | 10.47363/JPSRR/2024(6)173 |
| 2024 | Oral Testosterone Therapy in Hypogonadal Men: A Comprehensive Systematic Review and Meta-Analysis of Safety, Efficacy, and Secondary Health Outcomes | J. Series Endocrinology & Diabetes Metabolism | 10.54178/jsedmv6i3001 |
| 2024 | The Promise and Challenges of Oral Testosterone | MedNEXT J. Medical and Health Sciences | 10.54448/MDNT24406 |
| 2024 | Religiosity, Spirituality, and Nutrology in Palliative Care | Int. J. Nutrology (Indexed) | 10.54448/IJN24409 |
| 2024 | Emerging Digital Health Interventions for CVD | SSRN · Lancet Digital Health preprint track | SSRN 4981082 |
| 2024 | DIG Trial Subgroup Analysis on Renal Function and Digoxin | Harvard Medical School GCSRT · Harvard Dataverse | 10.7910/DVN/ZHYHY5 |
| 2024 | Machine Learning Framework for Early Cardiovascular Risk Detection | Harvard Dataverse · Dataset | 10.7910/DVN/ZRUWIV |
| 2026 | Iron Overload and Male Hypogonadism: A Systematic Review of the Hypothalamic Pituitary Gonadal Axis and Ferritin Related Burden Thresholds | Forthcoming (with Eberwein R.) | In production |
V.
Long form work
Book.
| Year | Title | ISBN | DOI |
|---|---|---|---|
| 2024 | Functional Foods and Nutraceuticals | 978 · 65 · 983826 · 2 | 10.54448/MSP.978-65-983826-2-9 |
VI.
Consolidated references
Discovery and verification.
Cross platform discovery of the canonical scholarly record. Primary source correspondence available on request for academic, credentialing, or regulatory verification.